The head of the laboratory, YERBOL BURASHEV, PhD in the specialty “6D060700-Biology”, is a specialist in the field of molecular biology, virology, monitoring and epidemiology of infectious diseases.
He was the performer of such projects as “Studying the process of pathogenesis of the influenza virus when changing the antigenic structure by three-dimensional modeling of proteins”, “Studying the antiviral activity of drugs against the SARS-COV-2 virus in vitro and conducting molecular epidemiological analysis of circulating COVID-19 strains”, as well as responsible performer of the STP “Coronavirus infection COVID-19 vaccine development”, as well as the performer of the grant financing project “Monitoring of arboviruses in the territory of the Republic of Kazakhstan”.
Currently, he is the manager and performer of the following projects and scientific and technical programs:
- manager of the project IRN AP19676553 “Epidemiological monitoring and development of modern diagnostic tools for particularly dangerous viral diseases of birds”;
- performer of the project IRN AR19678678 “Prevalence and genetic diversity of flaviaviruses in Kazakhstan”;
- performer of the STP according to the state task “Biological safety services in the field of science”, conducted under the program 070 “Protection of public health” under subprogram 100 “Ensuring sanitary and epidemiological welfare of the population”.
During the Covid-19 pandemic, Ye. Burashev was the responsible performer of the “PTF of the MES RK-OT-22 Development of COVID-19 coronavirus infection vaccine” in the direction of “Studying the molecular genetic properties of the COVID-19 pathogen”. According to the results of the STP, Ye. Burashev was awarded the medal “Халық алғысы (Halyk algysy – People’s Gratitude)” and the badge “Денсаулық сақтау ісінің үздігі (Densaulyk Saktau isinin uzdigi – Outstanding worker of Health care)”.
Over the past five years (since 2018), he has published 36 scientific articles, including 15 in journals indexed by WoS and Scopus, 12 in Kazakhstani journals, including those recommended by the Committee for Control in the Field of Education and Science of the Ministry of Education and Science of the Republic of Kazakhstan. In addition, since 2011 he has been the author of 7 inventions, of which 3 have been introduced into production in the field of veterinary medicine.
The citation index (Hirsch index) of Ye. Burashev over the past three years according to the information base WoS – 5, according to Scopus – 6.
Ye. Burashev takes an active part in the public life of the Institute. In 2015-2021, he was the chairman of the Council of Young Scientists of the RIBSP and, by virtue of his social activities, actively participated in organizing competitions, seminars and international conferences for the Institute’s staff.
Ye. Burashev was a deputy of the Maslikhat of the Kordai district of the VII convocation from August 2021 to January 2023. In the course of completing the tasks set, he was awarded the title of “Honorary Deputy” of the district maslikhat, and was also awarded the order of ” Ізгілік (Izgilk – Beneficence)”.
The laboratory is one of the key departments, which has an experimental base (BSL-2), which allows conducting research at a modern level. The BSL-2 laboratory was built as part of the Biological Threat Reduction Program (BTRP).
Main tasks:
- Research in the field of biotechnology, epizootology and molecular epizootology;
- epizootological monitoring of especially dangerous diseases;
- development of modern tools and methods for the diagnosis and prevention of animal diseases.
Main achievements
— Lumpy skin disease vaccine out of the “Neethling-RIBSP” strain
— Inactivated vaccine QazCovid-in® (QazVac) for the prevention of coronavirus infection COVID-19
— Capripoxvirus-based QazCovid- CPV vector vaccine for the prevention of COVID-19 coronavirus infection
— Cattle trichophytosis vaccine
— Carnivorous plague culture virus vaccine out of the “LD” strain
— Plague, infectious hepatitis and parvovirus enteritis of carnivores vaccine
— Therapeutic and prophylactic serum for plague, infectious hepatitis and parvovirus enteritis of carnivores.
Main publications:
— Orynbayev M.B., Hitch A.T., Kerimbayev A.А., Nisanova R.K., Sultankulova K.T., Rystayeva R.A., Omarova Z. D., Kassenov M.M., Tailakova E.T., Smith G.J.D., Mendenhall I.H. Serological exposure in Bactrian and dromedary camels in Kazakhstan to a MERS or MERS-like coronavirus. Transboundary and Emerging Diseases 2022 Sep;69(5):e1374-e1381. DOI: 10.1111/tbed.14468
— Khairullin B., Zakarya K., Orynbayev M., Abduraimov Y., Kassenov M., Sarsenbayeva G., Sultankulova K., Chervyakova O., Myrzhakhmetova B., Nakhanov A., Nurpeisova A., Zhugunissov K., Assanzhanova N., Nurabayev S., Kerimbayev A., Ershebulov Z., Burashev Y., Kulmagambetov I., Davlyatshin T., Sergeeva M., Buzitskaya Z., Stukova M., Kutumbetov L. Efficacy and safety of an inactivated whole-virion vaccine against COVID-19, QazCovid-in®, in healthy adults: A multicentre, randomised, single-blind, placebo-controlled phase 3 clinical trial with a 6-month follow-up. eClinicalMedicine, V.50,2022, https://doi.org/10.1016/j.eclinm.2022.101526.
Chervyakova, O.; Issabek, A.; Sultankulova, K.; Bopi, A.; Kozhabergenov, N.; Omarova, Z.; Tulendibayev, A.; Aubakir, N.; Orynbayev, M. Lumpy Skin Disease Virus with Four Knocked Out Genes Was Attenuated In Vivo and Protects Cattle from Infection. Vaccines 2022, 10, 1705. https://doi.org/10.3390/vaccines10101705
— Sultankulova K.T., Shynybekova G.O., Issabek A.U., Mukhami N.N., Melisbek A.M., Chervyakova O.V., Kozhabergenov N.S., Barmak S.M., Bopi A.K., Omarova Z.D., Alibekova D.A., Argimbayeva T.U., Namet A.M., Zuban I.A., Orynbayev M.B. The prevalence of pathogens among ticks collected from livestock in Kazakhstan. Pathogens 2022, 11, 1206. https://doi.org/10.3390/pathogens11101206
— Karagulov A.I., Argimbaeva T.U., Omarova Z.D., Tulendibaev A.B. , Dushaeva L. Zh., Aubakir N.A., Melisbek A.M., Sultankulova K.T., Alibekova D.A., Nametov A.M., Lozovoy D.A. , Orynbayev M.B. The Prevalence of Viral Pathogens among Bats in Kazakhstan. Viruses 2022, 14, 2743. https://doi.org/10.3390/v14122743
— Chervyakova, O.; Issabek, A.; Sultankulova, K.; Bopi, A.; Kozhabergenov, N.; Omarova, Z.; Tulendibayev, A.; Aubakir, N.; Orynbayev, M. Lumpy Skin Disease Virus with Four Knocked Out Genes Was Attenuated In Vivo and Protects Cattle from Infection. Vaccines 2022, 10, 1705. https://doi.org/10.3390/vaccines10101705
— Sultankulova K.T., Dzhekebekov K., Orynbayev M.B., Burashev Ye.D., Melisbek A.M., Barmak S.M., Kozhabergenov N., Issabek A.U., Chervyakova O.V., Namet A.M., Zakarya K., Fereidouni S. Evidence for flock transmission of individual subtypes and strains of avian influenza viruses: A monitoring study of wild birds in Kazakhstan. Virus Research 320 (2022) 198898, https://doi.org/10.1016/j.virusres.2022.198898
— Orynbayev M.B., Nissanova R.K., Kopeyev S.K., Issimov A., Zakarya K.D., Sultankulova K.T., Kutumbetov L.B., Tulendibayev A.B., Myrzakhmetova B., Burashev E.D., Chervaykova O.V., Nurabayev S.S., Nakhanov A.K., Kock R.A. 2021. Lumpy skin disease in Kazakhstan. Tropical Animal Health and Production (2021) 53:166 https://doi.org/10.1007/s11250-021-02613-6
— Sultankulova K.T., Shynybekova G.O., Issabek A.U., Mukhami N.N., Melisbek A.M., Chervyakova O.V., Kozhabergenov N.S., Barmak S.M., Bopi A.K., Omarova Z.D., Alibekova D.A., Argimbayeva T.U., Namet A.M., Zuban I.A., Orynbayev M.B. The Prevalence of Pathogens among Ticks Collected from Livestock in Kazakhstan. Pathogens 2022, 11, 1206. https://doi.org/10.3390/pathogens11101206
— Zakarya K., Kutumbetov L., Orynbayev M., Abduraimov Y., Sultankulova K., Kassenov M., Sarsenbayeva1 G., Kulmagambetov I., Davlyatshin T., Stukova M., Khairullin B. Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: a randomized, single-blind, placebo-controlled phase 1 clinical trial with a 6 months follow-up and an open-label phase 2 clinical trial in Kazakhstan. eClinicalMedicine, 00 (2021) 101078 https://doi.org/10.1016/j.eclinm.2021.101078.
— Zhugunissov K, Zakarya K, Khairullin B, Orynbayev M, Abduraimov Y, Kassenov M, Sultankulova K, Kerimbayev A, Nurabayev S, Myrzakhmetova B, Nakhanov A, Nurpeisova A, Chervyakova O, Assanzhanova N, Burashev Y, Mambetaliyev M, Azanbekova M, Kopeyev S, Kozhabergenov N, Issabek A, Tuyskanova M and Kutumbetov L (2021) Development of the Inactivated QazCovid-in Vaccine: Protective Efficacy of the Vaccine in Syrian Hamsters. Front. Microbiol. 12:720437. DOI: 10.3389/fmicb.2021.720437
— Fereidouni S., Freimanis G., Orynbayev M., Ribeca P., Flannery J., King D., Zuther S., Beer M., Hoper D., Kydyrmanov A., Karamendin K., Kock R. Mass mortality of Saiga antelopes in Kazakhstan in 2015, results of NGS investigation. Emerging Infectious Diseases Vol. 25, No. 6, June 2019, p.1136-1143 DOI: https://doi.org/10.3201/eid2506.180990
— Mendenhall I. H., Kerimbayev A.A., Strochkov V.M., Sultankulova K.T., Kopeyev S.K., Su Yvonne CF, Smith G JD, Orynbayev M.B. Discovery and characterization of novel bat coronavirus lineages from Kazakhstan. Viruses 2019, 11, 356; DOI: 10.3390/v11040356
— Robinson S., Milner-Gulland E.J., Grachev Y., Zuther S., Orynbayev M., Lushchenkina A., Morgan E., Beauvais W., Singh N., Khomenko S., Cammack R., Kock R. (2019) Opportunistic bacteria and mass mortality in ungulates: lessons from an extreme event. Ecosphere 10(6):e02671. DOI https://doi.org/10.1002/ecs2.2671
— Orynbayev M., Sultankulova K., Sansyzbay A., Rystayeva R., Shorayeva K.., Namet A., Fereidouni S., Ilgekbayeva G., Barakbayev K., Kopeyev S., Kock R. Biological Characterization of Pasteurella multocida Circulating in Saiga Population // BMC Microbiology. — 2019. — 19:37. DOI https://doi.org/10.1186/s12866-019-1407-9
— Orynbayev M.B., Fereidouni S., Sansyzbai A.R., Seidakhmetova B., Strochkov V. M., Nametov A.M., Sadikaliyeva S.O., Nurgazieva A., Tabynov K.K., Rametov N. M., Sultankulova K.T. (2018) Genetic diversity of Avian avulavirus-1 (Newcastle disease virus genotypes VIg and VIIb) circulating in wild birds in Kazakhstan // Arch Virol. DOI: 10.1007/s00705-018-3815-9
— Kock R., Orynbayev M., Robinson S., Zuther S., Singh N., Beauvais W., Morgan E. R., Kerimbayev A., Khomenko S., Martineau H., Rystaeva R., Omarova Z., Wolfs S., Hawotte F., Radoux J., Milner-Gulland E.J. Saigas on the brink: multi-disciplinary analysis of the factors influencing a mass die-off event // Sci. Adv. – 2018. – 4. — 2314. DOI: 10.1126/sciadv.aao2314
— Sultankulova K.T. Kozhabergenov N.S., Strochkov V.M., Burashev Y.D., Shorayeva K.A., Chervyakova O.V., Rametov N.M., Sandybayev N.T., Sansyzbay A.R., Orynbayev M.B. New oligonucleotide microarray for rapid diagnosis of avian viral diseases. Virology Journal (2017) 14:69 DOI https://doi.org/10.1186/s12985-017-0738-0
— Beauvais W., Orynbayev M., Guitian J. Empirical Bayes estimation of farm prevalence adjusting for multistage sampling and uncertainty in test performance: a Brucella cross-sectional serostudy in southern Kazakhstan // Epidemiol. Infect. – 2016. — 144(16). – Р. 3531-3539. DOI: 10.1017/S0950268816001825
— Orynbayev M.B., Beauvais W., Sansyzbay A.R., Rystaeva R.A., Sultankulova K.T., Kerimbaev A.A., Kospanova M.N., Kock R.A. Seroprevalence of infectious diseases in saiga antelope (Saiga tatarica tatarica) in Kazakhstan 2012-2014 // Prev Vet Med. – 2016. – 127. – Р. 100-104. DOI: 10.1016/j.prevetmed.2016.03.016
— Kock R.A., Orynbayev M.B., Sultankulova K.T., Strochkov V.M., Omarova Z.D., Shalgynbayev E.K., Rametov N.M., Sansyzbay A.R., Parida S. Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan // Transbound Emerg Dis. – 2015. — 62(5). – Р. 470-479. DOI: 10.1111/tbed.12398
Provision of services:
- Diagnosis of particularly dangerous diseases of wild and farm animals and birds.
- Development of recommendations for the improvement of farms from diseases.