Laboratory for Monitoring of Infectious Diseases


Head of the laboratory Orynbaev Mukhit Barmakuly, candidate of veterinary sciences, professor, corresponding member of the National Academy of Sciences of the Republic of Kazakhstan. Scientific interests are related to the study of especially dangerous pathogens, the development of specific means for the prevention and diagnosis of infectious diseases. More than 30 years of experience in research to improve outbreak response and surveillance of especially dangerous diseases. Author of more than 300 scientific papers, including 50 inventions, 4 monographs and 1 textbook, 17 normative and technical documents for the production and control of diagnostic and preventive drugs. Member of the National Scientific Council in the direction of “Science of Life and Health” (since 2020). Winner of the State Scientific Scholarship (2018-19). He was awarded the medal “Khalyk algysy” (2020), the badge “For merits in the development of science of the Republic of Kazakhstan” (2010). Laureate of the Al-Farabi State Prize in Science and Technology (2021). Hirsch index (h-index) according to Web of Science and Scopus – 9.0.

The laboratory is one of the key divisions, which has an experimental base (BSL-2), which allows conducting scientific research at the modern level. The BSL-2 laboratory was built as part of the Biological Threat Reduction Program (BHRP).


Main tasks:

  • research in the field of biotechnology, epizootology and molecular epizootology;
  • epizootic monitoring of especially dangerous diseases;
  • development of modern tools and methods for diagnosing and preventing animal diseases.


Main achievements

– Vaccine against lumpy skin disease from the Neethling-RIBSP strain

– Inactivated vaccine QazCovid-in® (QazVac) for the prevention of coronavirus infection COVID-19

– Vector vaccine QazCovid-CPV based on capripoxvirus for the prevention of coronavirus infection COVID-19

– Vaccine against trichophytosis of cattle

– Cultural virus vaccine from the strain “LD” against canine distemper

– Vaccine against plague, infectious hepatitis and carnivorous parvovirus enteritis

– Treatment and prophylactic serum for plague, infectious hepatitis and carnivorous parvovirus enteritis.


Main publications:

– Orynbayev M.B., Hitch A.T., Kerimbayev A.А., Nisanova R.K., Sultankulova K.T., Rystayeva R.A., Omarova Z. D., Kassenov M.M., Tailakova E.T., Smith G.J.D., Mendenhall I.H. Serological exposure in Bactrian and dromedary camels in Kazakhstan to a MERS or MERS-like coronavirus. Transboundary and Emerging Diseases 10.1111/tbed.14468

– Khairullin B., Zakarya K., Orynbayev M., Abduraimov Y., Kassenov M., Sarsenbayeva G., Sultankulova K., Chervyakova O., Myrzhakhmetova B., Nakhanov A., Nurpeisova A., Zhugunissov K., Assanzhanova N., Nurabayev S., Kerimbayev A., Ershebulov Z., Burashev Y., Kulmagambetov I., Davlyatshin T., Sergeeva M., Buzitskaya Z., Stukova M., Kutumbetov L. Efficacy and safety of an inactivated whole-virion vaccine against COVID-19, QazCovid-in®,  in healthy adults: A multicentre, randomised, single-blind, placebo-controlled phase 3 clinical trial with a 6-month follow-up. eClinicalMedicine, V.50,2022,

– Chervyakova, O.; Issabek, A.; Sultankulova, K.; Bopi, A.; Kozhabergenov, N.; Omarova, Z.; Tulendibayev, A.; Aubakir, N.; Orynbayev, M. Lumpy Skin Disease Virus with Four Knocked Out Genes Was Attenuated In Vivo and Protects Cattle from Infection. Vaccines 2022, 10, 1705.  

– Sultankulova K.T., Dzhekebekov K., Orynbayev M.B., Burashev Ye.D., Melisbek A.M., Barmak S.M., Kozhabergenov N., Issabek A.U., Chervyakova O.V., Namet A.M., Zakarya K., Fereidouni S. Evidence for flock transmission of individual subtypes and strains of avian influenza viruses: A monitoring study of wild birds in Kazakhstan. Virus Research 320 (2022) 198898,

– Orynbayev M.B., Nissanova R.K., Kopeyev S.K., Issimov A., Zakarya K.D., Sultankulova K.T., Kutumbetov L.B., Tulendibayev A.B., Myrzakhmetova B., Burashev E.D., Chervaykova O.V.,  Nurabayev S.S., Nakhanov A.K., Kock R.A. 2021. Lumpy skin disease in Kazakhstan. Tropical Animal Health and Production (2021) 53:166

– Sultankulova K.T., Shynybekova G.O., Issabek A.U., Mukhami N.N., Melisbek A.M., Chervyakova O.V., Kozhabergenov N.S., Barmak S.M., Bopi A.K., Omarova Z.D., Alibekova D.A., Argimbayeva T.U., Namet A.M., Zuban I.A., Orynbayev M.B. The Prevalence of Pathogens among Ticks Collected from Livestock in Kazakhstan. Pathogens 2022, 11, 1206.

– Zakarya K., Kutumbetov L., Orynbayev M., Abduraimov Y., Sultankulova K., Kassenov M., Sarsenbayeva1 G., Kulmagambetov I., Davlyatshin T., Stukova M., Khairullin B. Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: a randomized, single-blind, placebo-controlled phase 1 clinical trial with a 6 months follow-up and an open-label phase 2 clinical trial in Kazakhstan. eClinicalMedicine, 00 (2021) 101078

– Zhugunissov K, Zakarya K, Khairullin B, Orynbayev M, Abduraimov Y, Kassenov M, Sultankulova K, Kerimbayev A, Nurabayev S, Myrzakhmetova B, Nakhanov A, Nurpeisova A, Chervyakova O, Assanzhanova N, Burashev Y, Mambetaliyev M, Azanbekova M, Kopeyev S, Kozhabergenov N, Issabek A, Tuyskanova M and Kutumbetov L (2021) Development of the Inactivated QazCovid-in Vaccine: Protective Efficacy of the Vaccine in Syrian Hamsters. Front. Microbiol. 12:720437. doi:10.3389/fmicb.2021.720437

– Fereidouni S., Freimanis G., Orynbayev M., Ribeca P., Flannery J., King D., Zuther S., Beer M., Hoper D., Kydyrmanov A., Karamendin K., Kock R.  Mass mortality of Saiga antelopes in Kazakhstan in 2015, results of NGS investigation. Emerging Infectious Diseases Vol. 25, No. 6, June 2019, p.1136-1143 DOI:

– Mendenhall I. H., Kerimbayev A.A., Strochkov V.M., Sultankulova K.T., Kopeyev S.K., Su Yvonne CF, Smith G JD, Orynbayev M.B. Discovery and characterization of novel bat coronavirus lineages from Kazakhstan. Viruses 2019, 11, 356; doi:10.3390/v11040356

– Robinson S., Milner-Gulland E.J., Grachev Y., Zuther S., Orynbayev M., Lushchenkina A., Morgan E., Beauvais W., Singh N., Khomenko S., Cammack R., Kock R. (2019) Opportunistic bacteria and mass mortality in ungulates: lessons from an extreme event. Ecosphere 10(6):e02671. 10.1002/ecs2.267

– Orynbayev M., Sultankulova K., Sansyzbay A., Rystayeva R., Shorayeva K.., Namet A., Fereidouni S., Ilgekbayeva G., Barakbayev K., Kopeyev S., Kock R. Biological Characterization of Pasteurella multocida Circulating in Saiga Population // BMC Microbiology. — 2019. — 19:37.

– Orynbayev M.B., Fereidouni S., Sansyzbai A.R., Seidakhmetova B., Strochkov V. M., Nametov A.M., Sadikaliyeva S.O., Nurgazieva A., Tabynov K.K., Rametov N. M., Sultankulova K.T. (2018) Genetic diversity of Avian avulavirus-1 (Newcastle disease virus genotypes VIg and VIIb) circulating in wild birds in Kazakhstan // Arch Virol. DOI:10.1007/s00705-018-3815-9.

– Kock R., Orynbayev M., Robinson S., Zuther S., Singh N., Beauvais W., Morgan E. R., Kerimbayev A., Khomenko S., Martineau H., Rystaeva R., Omarova Z., Wolfs S., Hawotte F., Radoux J., Milner-Gulland E.J. Saigas on the brink: multi-disciplinary analysis of the factors influencing a mass die-off event // Sci. Adv. – 2018. – 4. — 2314. 

– Sultankulova K.T. Kozhabergenov N.S., Strochkov V.M., Burashev Y.D., Shorayeva K.A., Chervyakova O.V., Rametov N.M., Sandybayev N.T., Sansyzbay A.R., Orynbayev M.B. New oligonucleotide microarray for rapid diagnosis of avian viral diseases.  Virology Journal (2017) 14:69 DOI10.1186/s12985-017-0738-0.

– Beauvais W., Orynbayev M., Guitian J. Empirical Bayes estimation of farm prevalence adjusting for multistage sampling and uncertainty in test performance: a Brucella cross-sectional serostudy in southern Kazakhstan // Epidemiol. Infect. – 2016. — 144(16). – Р. 3531-3539.

– Orynbayev M.B., Beauvais W., Sansyzbay A.R., Rystaeva R.A., Sultankulova K.T., Kerimbaev A.A., Kospanova M.N., Kock R.A. Seroprevalence of infectious diseases in saiga antelope (Saiga tatarica tatarica) in Kazakhstan 2012-2014 // Prev Vet Med. – 2016. – 127. – Р. 100-104.

– Kock R.A., Orynbayev M.B., Sultankulova K.T., Strochkov V.M., Omarova Z.D., Shalgynbayev E.K., Rametov N.M., Sansyzbay A.R., Parida S. Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan // Transbound Emerg Dis. – 2015. — 62(5). – Р. 470-479.


Provision of services:

  • Diagnosis of especially dangerous diseases of wild and farm animals and birds.
  • Development of recommendations for the improvement of farms from diseases.



Work number: +7(72636)7-22-28, it. 136